Rosetta Mcp Server
Let your coding agent run Rosetta/PyRosetta protein workflows and Biotite structure handling without hand-rolling subprocess glue.
Overview
io.github.Arielbs/rosetta-mcp-server is a Build-phase MCP server that connects agents to Rosetta/PyRosetta protein modeling and Biotite translation on your machine.
What is this MCP server?
- stdio MCP server (npm package rosetta-mcp-server) v1.3.1
- Rosetta/PyRosetta protein modeling exposed to the agent
- Biotite translation for computational biology structures
- Configurable ROSETTA_BIN, PYTHON_BIN, and MCP_DEBUG env vars
- GitHub source: Arielbs/rosetta-mcp-server
- Server version 1.3.1
- stdio transport via npm identifier rosetta-mcp-server
- 3 documented environment variables: ROSETTA_BIN, PYTHON_BIN, MCP_DEBUG
Community signal: 16 GitHub stars.
What problem does it solve?
Agents cannot safely run Rosetta or Biotite pipelines when every project reinvents paths, Python envs, and binary invocation.
Who is it for?
Indie bioinformatics builders, structural-biology side projects, or lab-adjacent tools that already install Rosetta and PyRosette locally.
Skip if: General web SaaS founders with no protein-modeling requirements or teams unwilling to maintain Rosetta and PyRosetta installs.
What do I get? / Deliverables
After registration, your agent can invoke standardized Rosetta/Biotite operations using your configured binaries and Python environment.
- Agent-callable Rosetta/PyRosetta modeling workflows on your machine
- Biotite-backed structure translation steps inside chat-driven sessions
- Repeatable env-driven setup documented via ROSETTA_BIN and PYTHON_BIN
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Journey fit
Canonical shelf is Build because the value is wiring external scientific compute into the agent toolchain, not early market research or post-launch ops. Integrations fits an MCP stdio bridge that depends on local ROSETTA_BIN and a Python stack with PyRosetta/Biotite.
How it compares
Specialized scientific-compute MCP bridge, not a generic cloud API skill or browser automation server.
Common Questions / FAQ
Who is io.github.Arielbs/rosetta-mcp-server for?
Solo builders and small teams shipping computational-biology or structural-biology features who want Claude or Cursor to call Rosetta and Biotite through MCP.
When should I use io.github.Arielbs/rosetta-mcp-server?
Use it during Build when you are integrating agent-driven protein modeling, structure manipulation, or Biotite-based translation into your repo or research workflow.
How do I add io.github.Arielbs/rosetta-mcp-server to my agent?
Install the npm stdio package rosetta-mcp-server, set ROSETTA_BIN and PYTHON_BIN (and optional MCP_DEBUG), then register the server in your Claude Code, Cursor, or Codex MCP config.